Semax

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Semax peptide: a synthetic heptapeptide analog of adrenocorticotropic hormone (ACTH) fragment 4-10. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, semax is a research-grade neuropeptide available from Maple Research Labs with greater than 99%+ HPLC-verified purity and batch-specific COA.

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Product Specifications

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• Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (ACTH(4-10) with Pro-Gly-Pro extension)

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• Molecular Weight: Approximately 813 Da

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• Purity: >99%+ (HPLC verified)

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• Form: Lyophilized powder

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• Quantity: 5mg per vial

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Semax Peptide Research Summary

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Semax is a synthetic analog of the ACTH(4-10) fragment, a seven-amino acid sequence derived from adrenocorticotropic hormone that lacks the steroidogenic activity of the full-length hormone. It contains the ACTH(4-10) core sequence with a Pro-Gly-Pro C-terminal extension designed to improve metabolic stability while preserving the neuropeptide activities of the ACTH fragment.

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Mechanism of Action Research

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Published research has examined semax interactions with neurotrophic factor systems, particularly BDNF and NGF signaling. Studies in rodent models have reported that semax administration modulates BDNF and trkB receptor expression in hippocampal and cortical brain regions. Research has also investigated effects on dopaminergic and serotonergic signaling in specific brain regions.

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All findings are from preclinical animal and in vitro studies. No therapeutic claims are made.

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Certificate of Analysis (COA)

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Testing Laboratory: Testides Analytical. Purity (HPLC-UV): 99.90%. Report: DBAV-SEMAX-10-062226. Download Full COA (PDF)

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For research purposes only. Not for human consumption. Not for diagnostic or therapeutic use.