Semax

Semax peptide: a synthetic heptapeptide analog of adrenocorticotropic hormone (ACTH) fragment 4-10. Developed at the Institute of Molecular Genetics of the Russian Academy of Sciences, semax is a research-grade neuropeptide available from Maple Research Labs with greater than 99%+ HPLC-verified purity and batch-specific COA.

Product Specifications

• Sequence: Met-Glu-His-Phe-Pro-Gly-Pro (ACTH(4-10) with Pro-Gly-Pro extension)
• Molecular Weight: Approximately 813 Da
• Purity: >99%+ (HPLC verified)
• Form: Lyophilized powder
• Quantity: 5mg per vial

Semax Peptide Research Summary

Semax is a synthetic analog of the ACTH(4-10) fragment, a seven-amino acid sequence derived from adrenocorticotropic hormone that lacks the steroidogenic activity of the full-length hormone. It contains the ACTH(4-10) core sequence with a Pro-Gly-Pro C-terminal extension designed to improve metabolic stability while preserving the neuropeptide activities of the ACTH fragment.

Mechanism of Action Research

Published research has examined semax interactions with neurotrophic factor systems, particularly BDNF and NGF signaling. Studies in rodent models have reported that semax administration modulates BDNF and trkB receptor expression in hippocampal and cortical brain regions. Research has also investigated effects on dopaminergic and serotonergic signaling in specific brain regions.

All findings are from preclinical animal and in vitro studies. No therapeutic claims are made.

Certificate of Analysis (COA)

Testing Laboratory: Testides Analytical. Purity (HPLC-UV): 99.90%. Report: DBAV-SEMAX-10-062226. Download Full COA (PDF)

For research purposes only. Not for human consumption. Not for diagnostic or therapeutic use.

About this Semax reference material

Semax is supplied by Maple Research Labs as a lyophilised powder in a sealed vial under catalogue reference XA5-MRL. Every vial is drawn from a single production batch and is released only against a batch-specific certificate of analysis. The batch documented for this listing was tested by Testides Analytical, an independent third-party laboratory, and the report reference is shown in the specification above.

Analytical specification for this Semax batch

Identity and purity were determined by high-performance liquid chromatography with ultraviolet detection (HPLC-UV) and reported at 99.90%. The material is registered under CAS 80714-61-0, molecular formula C37H51N9O10S. HPLC-UV separates the target compound from related substances and process impurities and quantifies each as a percentage of total peak area, which is why the result is stated to two decimal places rather than as a rounded claim. Public registry data for CAS 80714-61-0 can be checked independently via PubChem.

What a batch-specific COA means

A batch-specific certificate describes the exact material in the vial being shipped, not a representative sample from an earlier production run. Where a supplier publishes a single document covering an entire product line, that certificate cannot describe the unit received. Maple Research Labs does not publish a Semax listing without a matching batch document, and the certificate for this batch is downloadable from this page.

Handling and storage

Supplied as a lyophilised powder. Store sealed vials away from light and moisture; refrigeration extends the shelf stability of the dry powder. Allow a chilled vial to reach ambient temperature before opening, to limit condensation on the stopper. Handle in a controlled laboratory environment using appropriate personal protective equipment, and record the batch reference against your own experimental documentation.

Availability and shipping

Orders ship from the United States. Semax is listed as a single vial, so a laboratory can verify the certificate and the material against its own analytical methods before committing to a larger order.

For research purposes only. Not for human consumption. Not for diagnostic or therapeutic use.

Third-party testing and traceability for Semax

Testing for Semax is commissioned from Testides Analytical, a laboratory independent of both Maple Research Labs and the manufacturer. Independent testing matters because an in-house result is produced by the party with an interest in the outcome, and a third-party result is not. Each certificate states the analytical method used, the date of analysis and the batch identifier, so a result can be traced to a specific production run rather than to a product name in general.

Laboratories sourcing Semax for method development or comparative work generally need three things on file: a purity figure produced by a stated method, a batch identifier that matches the vial in hand, and a supplier willing to publish both before purchase rather than after. Those are the terms this listing is published on, and the certificate is available without an account or an enquiry.